Rational investigation of thyroid disease requires careful avoidance of over-investigation of minor abnormalities balanced with prompt diagnosis of serious health conditions.

This article summarises the literature around the pathophysiology of fibromyalgia, as well as the evidence on low-dose naltrexone as a potential treatment option.

Noncardiac chest pain is a cause of significant morbidity and can be responsible for a high personal cost and healthcare burden.

General practitioners are ideally placed to identify high-risk infantile haemangiomas and coordinate their management.

Molecular targeting agents are revolutionising treatment options, particularly poly adenosine diphosphate–ribose polymerase inhibitors, especially for patients with an underlying BRCA mutation.

The most commonly encountered swellings in the oral cavity are either submucosal in nature, or involve swelling of the underlying jaw (maxilla or mandible).

These multiple-choice and short answer questions are based on the Focus articles in this issue.

This is a case study on milk-alkali syndrome.

Two male patients aged in their 20s, who had no relationship with each other, separately presented with a three-month history of multiple asymptomatic papules on the genitalia.

A man aged 88 years was referred to a geriatric clinic for falls evaluation.

This issue describes aspects of modern cancer treatment and underscores the importance of general practitioners to achieve optimal whole-person care.

A man aged 62 years who worked as school cleaner presented with concerns of a blue-grey colouration to all his nails.

A male mechanic, aged 67 years, presents with a new-onset facial rash of six months’ duration.

A case presentation of a rapid-onset, painful rash that had developed over 24 hours.

When using topical options for treating low-grade lesions, it is important to inform the patient about possible treatment failure and the need to have another intervention if the lesion recurs.