This clinical challenge is based on this month’s Focus articles. To complete this activity, go to the RACGP website.

People who are immunosuppressed may benefit from deferring vaccination.

Immunosenescence, altered pharmacokinetics and the presence of multiple comorbidities can all affect response to immunosuppressants.

The host immune system appears to have a fundamental role in almost all human disease.

Readers express their opinions on published articles and topics of interest.

Better defining, integrating and supporting general practitioner roles in disaster systems is likely to improve disaster healthcare.

Pharmaceutical industry interactions with professional medical associations have come under scrutiny, yet industry ties among the leadership of these associations are often overlooked.

An individualised approach is needed to provide pre-travel health advice and immunisation.

General practitioners viewed the doctor–patient relationship as foundational to whole-person care, facilitating knowledge of the patient, trust and management.

While general practitioners have concerns about the use of data stored on electronic health records, they also recognise the benefits of using this data for research purposes.

Stigma communicated through words can affect people seeking help and undertaking treatment for their health issues.

Gamma hydroxybutyrate is associated with a disproportionate burden of harm despite low overall population prevalence of use.

Foot ulcers are an independent predictor of recurrent foot ulcers, foot surgery and amputation.

A man aged 61 years presented with a two-week history of epigastric discomfort, nausea and lethargy.

A male mechanic, aged 67 years, presents with a new-onset facial rash of six months’ duration.