Successful implementation of evidence-based medicine requires framing within the cultural and structural barriers Aboriginal and Torres Strait Islander people experience.

This issue focuses on rheumatology and includes articles on acute rheumatic fever, rheumatoid arthritis and the role of exercise in management of rheumatological disease.

Patients can be empowered through understanding chronic kidney disease as not confined to a single organ system but as the antecedent and consequence of several pathophysiological processes.

The Focus articles in this issue explore various aspects of chronic kidney disease, as well as cystitis symptoms in women.

Neurodiversity, which refers to variations between human minds occurring naturally within a population, is the focus of this month's issue.

General practitioners are well placed to support their neurodivergent patients once recognised, with or without a formal diagnosis.

The identification of hidden illnesses that present with vague symptoms remains an ongoing challenge for all clinicians.

The Focus articles in this month's issue explore a range of endocrine diseases that can be difficult to diagnose due to the oftentimes-vague symptoms.

Primary healthcare, with its established principles and multisectoral approach, is an ideal mechanism to provide support and care in response to health threats.

The COVID-19 pandemic, with its resulting city lockdowns, mass quarantines and social isolation worldwide, has uniquely highlighted the importance of mental health.

The specialty of orthopaedics includes management of musculoskeletal pathology of the upper limbs, spine and lower limbs across the lifespan, from the very young to the very old.

The specialty of orthopaedics includes management of musculoskeletal pathology of the upper limbs, spine and lower limbs across the lifespan, from the very young to the very old.

The COVID-19 pandemic has affected all aspects of our lives, including routine immunisation coverage.

Key immunisation issues include maternal vaccination, allergy, revaccination after vaccine-proximate seizures, BCG vaccination and the general practitioner’s role in the rollout of a COVID-19 vaccine.

Oral and dental health, as well as dental services, are important to general practice patients and need to be better integrated into general practitioners' thinking and practice.