Volume 48, Issue 12, December 2019

Heart on the wrong side

John O’Bryen    Nirija Ranjit Anderson    Joel Collins   
doi: 10.31128/AJGP-07-19-5019   |    Download article
Cite this article    BIBTEX    REFER    RIS


A man aged 19 years presented to a general practitioner (GP) with a one-day history of urinary frequency. There was no associated dysuria, macroscopic haematuria or urethral discharge. His history was unremarkable for previous urological conditions and sexual activity. On examination he was afebrile at 36.7°C. His abdomen was soft with no palpable masses, and examination of his genitalia was normal. A digital rectal examination was not performed. A urine dipstick indicated the presence of nitrites, leucocytes, blood and protein. A provisional diagnosis of urinary tract infection was made. The specimen was sent for microscopy, culture and sensitivities (MCS). The patient was prescribed trimethoprim 300 mg daily for seven days and advised he would need a follow-up appointment to discuss the MCS results and to arrange ultrasonography of his kidneys, ureters and bladder.

Incidentally, the GP noticed that the patient had a marfanoid appearance and obtained consent to examine for this. The patient’s height was 195.5 cm and weight was 64.3 kg, giving a body mass index of 16.82 kg/m2. He had long limbs with low muscle volume and long digits with hyperextendable joints. Inspection of the anterior chest revealed pectus carinatum and, to the GP’s surprise, a bounding apex beat on the right side of the chest within the fifth intercostal space. The patient’s left hemithorax was dull to percussion and had no breath sounds to auscultation. He was not tachypnoeic and had no increased work of breathing. It was noted that the patient was diaphoretic.

On further questioning, the patient admitted to worsening exertional dyspnoea for one month with associated orthopnoea when sleeping on his right side. He had also had a non-productive cough for the same duration. He had not sought medical advice for these symptoms as he attributed them to smoking, having smoked five cigarettes daily for the previous 1–2 years. He had not had any weight loss, had not travelled internationally and did not use recreational drugs. His alcohol intake was minimal.

The GP expressed concern about a sinister thoracic pathological process and requested the patient have a chest X-ray performed that afternoon. Despite telephone call reminders, the patient delayed the X-ray (Figure 1) until the following week because of commitments, and in this time he had increased exertional dyspnoea.

AJGP Clinical O'Bryen Heart on wrong side figure 1

Figure 1.
Chest X-ray showing a large left pleural effusion and mediastinal shift to the right

Question 1

What are possible causes of a pleural effusion?

Answer 1

The causes of a pleural effusion are typically considered under the categories of transudates and exudates (Table 1) on the basis of assessment of the pleural fluid according to Light’s criteria.1

Table 1. Causes of pleural effusions
Transudates Exudates
  • Heart failure
  • Liver cirrhosis
  • Kidney failure
  • Hypoalbuminaemia
  • Pneumonia
  • Malignancy
  • Pancreatitis
  • Autoimmune disease
  • Pulmonary infarction
  • Subphrenic abscess
  • Tuberculosis
  • Chylothorax
  • Medications

Case continued

The GP was contacted by the radiologist to discuss the chest X-ray findings. They proceeded immediately to a computed tomography (CT) scan of the chest, abdomen and pelvis (Figure 2), which provided additional findings of widespread lymphadenopathy, hepatosplenomegaly and sclerotic bone lesions. A provisional diagnosis of lymphoma was made on the basis of these findings; the patient was telephoned by the GP to inform him of the results and to arrange inpatient hospital admission via emergency. Formal urine MCS results, which identified a significant number of erythrocytes with no leucocytes and no pathogen isolated on culture, were also discussed. The urinary frequency and microscopic haematuria were attributed to the suspected lymphomatous process. During hospital admission, an additional history was elicited of three months of night sweats; an episode of epistaxis; and examination findings of palpable cervical, supraclavicular and axillary lymphadenopathy.

AJGP Clinical O'Bryen Heart on wrong side figure 2

Figure 2. Computed tomography of the chest

The patient was admitted under the haematology unit and thoracentesis was performed. Work-up identified several abnormalities including hypercalcaemia, anaemia, coagulopathy, raised lactate dehydrogenase and raised C-reactive protein (Table 2). A cervical lymph node biopsy confirmed classical Hodgkin lymphoma. Staging was consistent with stage IV (advanced-stage Hodgkin lymphoma). The patient commenced doxorubicin, bleomycin, vinblastine, dacarbazine (ABVD) as his initial treatment regimen because of the ability to administer it rapidly. He was subsequently escalated to bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisolone (BEACOPP) for a planned six cycles. The GP arranged a referral to clinical genetics to pursue the Marfan diagnosis; however, the patient moved interstate and did not follow this up. Continuation of management of his lymphoma was transferred to his local haematology service.

Table 2. Pathology results
Observation Value Reference range
Haemoglobin 116 g/L 135–180 g/L
White cell count 9.8 × 109/L 4.0–11.0 × 109/L
Platelet count 367 × 109/L 140–400 × 109/L
Haematocrit 0.37 0.39–0.52
Red cell count 4.60 × 1012/L 4.50–6.00 × 1012/L
Mean corpuscular volume 81 fL 80–100 fL
Neutrophils 8.80 × 109/L 2.00–8.00 × 109/L
Lymphocytes 0.26 × 109/L 1.00–4.00 × 109/L
Monocytes 0.61 × 109/L 0.10–1.00 × 109/L
Eosinophils 0.06 × 109/L <0.60 × 109/L
Basophils 0.02 × 109/L <0.20 × 109/L
International normalised ratio 1.7 0.9–1.2
Prothrombin time 18 s 9–13 s
Activated partial thromboplastin time 33 s 24–39 s
Fibrinogen (derived) 5.0 g/L 1.7–4.5 g/L
Sodium 136 mmol/L 135–145 mmol/L
Potassium 3.8 mmol/L 3.5–5.2 mmol/L
Chloride 96 mmol/L 95–110 mmol/L
Bicarbonate 29 mmol/L 22–32 mmol/L
Anion gap 11 mmol/L 4–13 mmol/L
Osmolality 286 mmol/L 275–295 mmol/L
Glucose 5.6 mmol/L 3.0–7.8 mmol/L
Urea 3.8 mmol/L 2.1–7.1 mmol/L
Creatinine 73 mmol/L 60–110 mmol/L
Urate 0.37 mmol/L 0.15–0.50 mmol/L
Protein 65 g/L 60–80 g/L
Albumin 27 g/L 35–50 g/L
Globulin 38 g/L 25–45 g/L
Bilirubin (total) 11 μmol/L <20 μmol/L
Bilirubin (conjugated) 5 μmol/L <4 μmol/L
Alkaline phosphatase 92 U/L 45–150 U/L
Gamma-glutamyl transferase 39 U/L <55 U/L
Alanine transaminase 8 U/L <45 U/L
Lactate dehydrogenase 282 U/L 120–250 U/L
Calcium 2.54 mmol/L 2.10–2.60 mmol/L
Calcium (corrected for albumin) 2.80 mmol/L 2.10–2.60 mmol/L
Phosphate 1.36 mmol/L 0.75–1.65 mmol/L
Magnesium 0.70 mmol/L 0.70–1.10 mmol/L
C-reactive protein 96 mg/L <5.0 mg/L

Question 2

What are typical presentations of Hodgkin lymphoma?

Question 3

How is the diagnosis of Hodgkin lymphoma confirmed?

Question 4

What is the staging system used?

Question 5

What is the significance of Marfan syndrome?

Answer 2

Typical presentations of Hodgkin lymphoma are asymptomatic lymphadenopathy, a mediastinal mass or ‘B symptoms’ (fever >38°C, weight loss and drenching sweats). A doctor must examine for lymphadenopathy and splenomegaly if these conditions are suspected. Hodgkin lymphoma has a bimodal age distribution with peaks among young adults and the elderly.

Answer 3

Histopathological diagnosis is required via tissue sampling, ideally using an excisional lymph node biopsy. A positron emission tomography/CT scan is required for staging, and a bone marrow biopsy is performed to assess marrow involvement.

Answer 4

The Cotswolds-modified Ann Arbor classification is used for staging.2 Stages are from I to IV with further sub-classifications. Patients may have early-stage disease (limited – stages I and II) or advanced-stage disease (stages III and IV). Early-stage disease is sub-classified into favourable and unfavourable depending on the presence of B symptoms, age and bulky disease. Disease stage is prognostic, in addition to several other patient parameters including age, sex and haematological parameters. Five-year survival for advanced-stage Hodgkin lymphoma ranges from 67% to 98% based on the patient’s International Prognostic Index score with ABVD treatment, and similar rates are reported for BEACOPP regimens.3

Given the favourable survival rates for patients with even highest-stage disease – especially in the fit, young patient population – a key focus is now management and prevention of longer-term therapy-related toxicities such as cardiopulmonary complications, as well as monitoring for secondary malignancies that may occur as a late complication of therapy.4 Novel targeted therapies currently in clinical trials promise to provide additional treatment options and reduce therapy complications.5

Answer 5

Individuals with Marfan syndrome should undergo monitoring for aortic dilatation, ectopia lentis, glaucoma, scoliosis and pectus deformities. They should receive genetic counselling and advice regarding appropriateness of pregnancy and high-intensity exercise given the risk of aortic dissection.6 There is suggestion that Marfan syndrome is associated with higher rates of malignancy.7

Key points

  • Typical presentations of Hodgkin lymphoma are asymptomatic lymphadenopathy, a mediastinal mass or B symptoms.
  • Histopathological diagnosis is required, ideally with an excisional lymph node biopsy.
  • Given favourable survival rates, a key focus is now on monitoring and management of therapy-related complications.
Competing interests: None.
Provenance and peer review: Not commissioned, externally peer reviewed.
Funding: None.
  1. Light RW. Clinical practice. Pleural effusion. N Engl J Med 2002;346(25):1971–77. doi: 10.1056/NEJMcp010731. Search PubMed
  2. Lister TA, Crowther D, Sutcliffe SB, et al. Report of a committee convened to discuss the evaluation and staging of patients with Hodgkin’s disease: Cotswolds meeting. J Clin Oncol 1989;7(11):1630–36. doi: 10.1200/JCO.1989.7.11.1630. Search PubMed
  3. Moccia AA, Donaldson J, Chhanabhai M, et al. International prognostic score in advanced-stage Hodgkin’s lymphoma: Altered utility in the modern era. J Clin Oncol 2012;30(27)3383–88. doi: 10.1200/JCO.2011.41.0910. Search PubMed
  4. Follows GA, Ardeshna KM, Barrington SF, et al. Guidelines for the first line management of classical Hodgkin lymphoma. Br J Haematol 2014;166(1):34–39. doi: 10.1111/bjh.12878. Search PubMed
  5. Arulogun S, Hertzberg M, Gandhi MK. Recent treatment advances in Hodgkin lymphoma: A concise review. Intern Med J 2016;46(12):1364–69. doi: 10.1111/imj.13051. Search PubMed
  6. Ades L. Guidelines for the diagnosis and management of Marfan syndrome. Heart Lung Circ 2007;16(1):28–30. doi: 10.1016/j.hlc.2006.10.022. Search PubMed
  7. Hsu CW, Wang JC, Liao WI, et al. Association between malignancies and Marfan syndrome: A population-based, nested case-control study in Taiwan. BMJ Open 2017;7(10):e017243. doi: 10.1136/bmjopen-2017-017243. Search PubMed

Case studyEmergency medicineLymphomaMediastinal shiftPneumothorax

Download article