Syphilis is increasingly prevalent across Australia and should always be included as part of a routine sexual health screen.

This article aims to describe recent epidemiological trends of syphilis infection in Australia, including demographics in which infection rates are rising, such as women of reproductive age.

A man aged 37 years presented with a three-day history of a penile ulcer and fatigue.

Syphilis is a great mimicker and should not be forgotten as a differential diagnosis of erythematous scaly rashes.