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Clinical challenge
Volume 52, Issue 4, April 2023

April 2023 Clinical challenge


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This issue of Australian Journal of General Practice (AJGP), including the articles and clinical challenge, is an RACGP Continuing Professional Development (CPD) program-approved activity (Activity ID: 457763) and is allocated a total of seven CPD hours. CPD points are self-declared.
Therefore, completion of all AJGP CPD activities equates to 77 hours per calendar year.

This includes:
• two hours’ Educational Activity: Reading the journal
• two hours’ Measuring Outcomes: Completion of the clinical challenge
• three hours’ Reviewing Performance: Self‑reflection.

Answers to the clinical challenge are published in the following edition of AJGP, and are available immediately following successful completion online at  www.racgp.org.au/education/professionaldevelopment/
online-learning/gplearning.

To complete this activity, go to the RACGP website. Once logged in, click on the My Account button and select the gplearning link from the drop-down.


These questions are based on the Focus articles in this issue. Please choose the single best answer for each question.

Case 1

Costa, a man aged 63 years, presents to your clinic to obtain his repeat prescriptions for hypertension.

Question 1

Which one of the following is recommended in nature prescribing?

  1. verbal counselling
  2. intermittent fasting
  3. ketogenic dieting
  4. strength training
Question 2

Prescriptions for nature prescribing, whether written or verbal, could include the type of activity, frequency and:

  1. limitation
  2. contraindication
  3. duration
  4. indication
Question 3

Which one of the following is a facilitator of nature prescribing?

  1. electronic devices
  2. link workers
  3. indoor plants
  4. written information

Case 2

Margaret, a woman aged 91 years, presents for routine review after a recent hospital admission for urinary tract infection.

Question 4

Deprescribing is a safe and effective method of reducing polypharmacy and:

  1. Alzheimer’s disease
  2. rheumatoid arthritis
  3. high-risk prescribing
  4. restrictive lung disease
Question 5

Patient-related barriers for deprescribing includes which one of the following?

  1. competing priorities
  2. personal beliefs and attitudes
  3. lack of clinician time
  4. lack of funding
Question 6

Polypharmacy might lead to the underprescribing of which one of the following?

  1. complementary medications
  2. nutritional supplements
  3. sedative medications
  4. indicated medications

Case 3

Nazia, a woman aged 39 years, presents with chronic pain and fatigue, in the setting of fibromyalgia.

Question 7

The precise pathogenesis of fibromyalgia remains unclear, but includes which one of the following?

  1. thyroid hormone derangement
  2. chronic substance abuse
  3. peripheral neurogenic inflammation
  4. psychiatric disturbance
Question 8

Patients with fibromyalgia often experience reduced:

  1. chronic disease
  2. oral hygiene
  3. social engagement
  4. appetite
Question 9

Low-dose naltrexone might improve symptoms in patients with fibromyalgia by changing the processes of central and peripheral:

  1. perception
  2. sensitisation
  3. somatisation
  4. categorisation

Case 4

Levi, a man aged 26 years, who is a body builder, would like to discuss the adverse effects of non-prescribed performance- enhancing drugs at his next consultation.

Question 10

Extremely common side effects of non-prescribed performance-enhancing drugs include which one of the following?

  1. depression
  2. eczema
  3. schizophrenia
  4. psoriasis

These questions are based on the Focus articles in this issue. Please write a concise and focused response to each question.

Case 1

Costa, a man aged 63 years, presents to your clinic to obtain his repeat prescriptions for hypertension.

Question 1

State what is meant by the term ‘nature prescribing’.

Question 2

State the difference between ‘green space’ and ‘blue space’ interventions in nature prescribing.

Question 3

List two facilitators of nature-based prescribing.

Case 2

Margaret, a woman aged 91 years, presents for routine review after a recent hospital admission for urinary tract infection.

Question 4

Define what is meant by the term ‘prescribing cascade’.

Question 5

State what is meant by the term ‘deprescribing’.

Question 6

Define what is meant by the term ‘polypharmacy’.

Question 7

Define what is meant by the term ‘potentially inappropriate medicines (PIMs)’.

Case 3

Nazia, a woman aged 39 years, presents with chronic pain and fatigue, in the setting of fibromyalgia.

Question 8

State the mechanism of action of low‑dose naltrexone.

Question 9

List three side effects of low-dose naltrexone.

Case 4

Levi, a man aged 26 years, who is a body builder, would like to discuss the adverse effects of non-prescribed performance-enhancing drugs at his next consultation.

Question 10

List three non-medical reasons why people might self-administer performance- and image-enhancing drugs (PIEDs).


March 2023 Clinical challenge answers

Answer 1: A

The most commonly diagnosed cancer in Australia and the most commonly diagnosed cancer among Australian men is prostate cancer.

Answer 2: D

The majority of low-risk prostate cancer in Australia and New Zealand is now treated with active surveillance or watchful waiting.

Answer 3: B

The negative predictive value and sensitivity of diagnosing clinically significant prostate cancer is increased with PMSA PET scans and MRI.

Answer 4: A

If the PI–RADS score is ≥3, mpMRI followed by a targeted prostate biopsy is superior to standard biopsy for detecting clinically significant cancers.

Answer 5: C

Men who have a raised PSA (>3) should undergo a second test ensuring that sexual activity did not take place for three to four days before the test, as ejaculation can result in a false positive.

Answer 6: B

The possibility of an asymptomatic urinary tract infection should be excluded in men with a PSA >3.

Answer 7: A

The European Association of Urology (EAU) guidelines suggest that biopsy may be omitted following negative MRI results (PI-RADS ≤2) after shared decision making.

Answer 8: D

Transperineal biopsies significantly reduce the risk of sepsis compared with transrectal biopsies; however, urinary retention occurs in 1.6–24% of patients following transperineal prostate biopsy.

Answer 9: A

Studies report rates of erectile dysfunction in up to 24% of patients following transperineal biopsy; however, this is usually transient and resolves within three months.

Answer 10: C

Risk-stratified recommendations based on the European Association of Urology (EAU) guidelines suggest offering early PSA testing to men with an elevated risk of having prostate cancer, such as men aged >45 years with a family history of prostate cancer.

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