Advances in genomic epidemiology and sequencing technology will change the way GPs practice medicine in the 21st century.

The genomics era is finally upon general practice, and we need to be prepared to meet the challenges it raises and reap its benefits.

Although rare, allopurinol-induced severe cutaneous adverse reactions and allopurinol hypersensitivity syndrome have significant morbidity and mortality consequences.

An update on the genetic basis of sudden cardiac death (SCD) in the young and the clinical aspects of caring for families affected by SCD.

Achievement of personalised cancer care requires a system-wide approach that targets the patient, healthcare provider and healthcare system with data informing practice.

New methods of detecting and treating spinal muscular atrophy can be increasingly complex to navigate for both healthcare professionals and at-risk families.

General practitioners are integrating genomic testing into care, mainly through prenatal screening, and anticipate further impact.