A man, aged 31 years, presented with a five-day history of worsening sore throat and a mixed macular–vesicular rash on his hands.

Evidence supports some beneficial effects of antibiotics prescribed to patients with a sore throat and proven presence of group A streptococci.

Consider Centor criteria before prescribing antibiotics in patients with a sore throat.

This article provides a narrative review of potential causes of globus pharyngeus and a suggested guideline for work-up and management in the primary care setting.