The Freo Street Doctor service is an accredited, mobile, open-access general practice service to improve primary healthcare for people who are homeless and marginalised.

Despite recent exponential growth in research on familial hypercholesterolaemia, there remains a general lack of public and health professional awareness about the disorder.

Screening and management in general practice has the potential for substantial health benefits while requiring relatively modest investments from the health system.

Primary care has much to offer in the future diagnosis and management of familial hypercholesterolaemia, but it requires greater awareness and a better appreciation of cumulative cholesterol burden.

Patient health literacy is a barrier to both management of familial hypercholesterolaemia and cascade testing.

Street-based general practice services are critical to facilitate easy access to primary and secondary management of chronic multimorbid conditions in marginalised patients.