These presentations provide fertile ground for educating patients about infections, self-management options, dealing with uncertainty and responsible use of medicines.

Challenges that multiple sclerosis presents include early detection, awareness of new therapies, work with multidisciplinary teams and its long-term management as a chronic disease.

Challenges that multiple sclerosis presents include early detection, awareness of new therapies, work with multidisciplinary teams and its long-term management as a chronic disease.

Medication cessation or dose reduction may be required for patients with chronic kidney disease to prevent medication accumulation, adverse medication events and kidney injury.

Patients with advanced age, significant comorbidities and poor functional status may not gain a survival benefit with dialysis when compared with being managed conservatively.

Buprenorphine–naloxone is well tolerated by patients with chronic pain, and has the potential to improve pain scores and affective symptoms.

Pretreatment assessment and correction of serum calcium and vitamin D levels can reduce the risk of denosumab-related hypocalcaemia in chronic kidney disease.

This paper describes the overall number of prescriptions and unique medicines dispensed and costs borne by a cohort of patients treated with lipid-lowering therapy.

This study assesses the influence of baseline body mass index and baseline knee pain on improvements in patients participating in a weight loss program for knee osteoarthritis.

This article outlines an approach for understanding, explaining and managing chronic pelvic pain in women with a normal laparoscopy.

General practitioners play a crucial part in screening, monitoring and early management of chronic kidney disease mineral and bone disorder (CKD-MBD) in patients with chronic kidney disease.

Lifestyle management should be included in communication plans, with referrals to other healthcare professionals as appropriate.

Cognitive impairment is common in multiple sclerosis and can have an impact on all aspects of daily life.

Cognitive rehabilitation is person-centred, with interventions chosen in collaboration with the person, based on biopsychosocial case formulation, and with the aim of meeting the person’s goals.

Asthma presentations are common in general practice, but opportunities to control asthma are often missed.