Multiple factors related to the immediate, local and broader contexts of care, together with overarching factors, influence its provision.

General practitioners believe that principles underlying Medical Homes may support whole-person care, but aspects of the current Health Care Homes trial could impede this whole-person approach.

Understanding the sophisticated craft and practical skills of generalist care could help both GPs and health policy makers value, respect and navigate the challenges of this complex important work.

General practitioners viewed the doctor–patient relationship as foundational to whole-person care, facilitating knowledge of the patient, trust and management.

The aim of this qualitative study was to determine how general practitioners understand whole-person care and its facilitators and barriers.