Patients can be empowered through understanding chronic kidney disease as not confined to a single organ system but as the antecedent and consequence of several pathophysiological processes.

The Focus articles in this issue explore various aspects of chronic kidney disease, as well as cystitis symptoms in women.

While it is important to investigate and understand the role of the BCG vaccine in other areas, this should not be at the expense of its proven use for tuberculosis protection.

More than 360 cardiovascular disease risk equations have been developed, many incorporating risk factors not included in the Framingham Risk Equation.

A greater emphasis on cardiovascular risk factor modification for all patients with peripheral artery disease is required to improve long-term outcomes.

Screening with immunological tests is not a proxy for the rational process of formulating a differential diagnosis.

Heart failure with preserved ejection fraction is an emerging global epidemic that requires increased awareness among the primary healthcare community.

An overview of the investigation and management of thyroid nodules in general practice.

This paper gives an overview of the breast skin changes commonly seen in general practice, with guidance on treatment and management.

Scabies, an under-appreciated global health concern, needs to be considered in the differential of any pruritic cutaneous dermatoses.

The purpose of this study was to develop a clinical prediction rule based on identified risk factors for surgical site infection in a large general practice patient cohort.

This article discusses how the carbon emissions from virtual consultations have the potential to be much smaller than in-person consultations, predominantly through reduced transportation.

This is a case study on toxic epidermal necrolysis.

This article discusses the assessment of acute- to subacute-onset erythematous and scaly plaques that are present on multiple body sites in a patient aged >65 years.

This study discusses the importance of recognising and treating postinflammatory hyperpigmentation in skin of colour because it can be a significant patient concern.