These presentations provide fertile ground for educating patients about infections, self-management options, dealing with uncertainty and responsible use of medicines.

A student aged 15 years was brought by his mother to a Malaysian suburban primary care clinic.

A woman aged 75 years presented to a general practitioner with a dry cough and increasing exertional dyspnoea for the preceding three years.

There is room for improvement in monitoring patients with early chronic kidney disease when considering alignment with national guidelines.

This paper provides an overview of exercise care in general practice to support sustained solutions for patients living with chronic disease.

The Focus articles in this issue explore COVID-19 renal disease, acute kidney injury, renal colic, paediatric urinary tract infections and haematuria.

The interface of general practice and kidney healthcare has never been more important than it is in our current pandemic world.

Patients can be empowered through understanding chronic kidney disease as not confined to a single organ system but as the antecedent and consequence of several pathophysiological processes.

The Focus articles in this issue explore various aspects of chronic kidney disease, as well as cystitis symptoms in women.

Psychological support provided by GPs is an important factor for the maintenance of a positive sense of wellbeing for patients with persistent pain.

Chronic non-cancer pain management illustrates the case for reconceptualising chronic condition management using a generic lifestyle-based approach.

The majority of referrals to a regional outpatient nephrology service contained insufficient detail to meet Australian guidelines.

This article aims to provide evidence-based information to GPs, aiding the decision to initiate sodium–glucose cotransporter 2 (SGLT2) inhibitors for chronic kidney disease patients.

This article investigates the prevalence of chronic pain in a rural setting and the use of specialist pain clinics and examines factors associated with well-managed pain.

Challenges that multiple sclerosis presents include early detection, awareness of new therapies, work with multidisciplinary teams and its long-term management as a chronic disease.