Patients with advanced age, significant comorbidities and poor functional status may not gain a survival benefit with dialysis when compared with being managed conservatively.

This paper considers common mechanisms underpinning chronic conditions and how these mechanisms might be targeted therapeutically in primary care.

Reaching blood pressure targets in patients with chronic kidney disease is a challenge, but can be more easily achieved with greater continuity of care.

Patient-centred practice is needed to build a treatment plan that works for individual patients.

This study shows the importance of sharing and learning from policy differences.

Australia’s outdated definition of obesity likely hinders management and contributes to the observed gap between clinical guidelines and current practice.

This article explores the themes of patient choice, safety and optimising success in GP-led withdrawal. The four-step framework outlines how to best support patients to undertake a withdrawal.

Health coaching is an integral part of lifestyle medicine that can be used to facilitate behaviour change in key lifestyle areas.

Living with haemochromatosis is an individual journey that requires consistent, medically supported self-management guided by a positive attitude and awareness of the condition.

There is a need to enhance aged care exposure for general practice registrars in ways that build on the competence of registrars and the trust in registrars by older patients and supervisors.

Medication cessation or dose reduction may be required for patients with chronic kidney disease to prevent medication accumulation, adverse medication events and kidney injury.

This paper provides an overview of exercise care in general practice to support sustained solutions for patients living with chronic disease.

The Focus articles in this issue explore COVID-19 renal disease, acute kidney injury, renal colic, paediatric urinary tract infections and haematuria.

The interface of general practice and kidney healthcare has never been more important than it is in our current pandemic world.

Patients can be empowered through understanding chronic kidney disease as not confined to a single organ system but as the antecedent and consequence of several pathophysiological processes.