This article provides an overview of the diagnosis of premature ovarian insufficiency and its management with respect to infertility.

Molecular targeting agents are revolutionising treatment options, particularly poly adenosine diphosphate–ribose polymerase inhibitors, especially for patients with an underlying BRCA mutation.

In this case study, a woman aged 72 years presents with abdominal discomfort and difficulty in micturition and defecation.

Extreme androgenisation in a female requires timely investigation.

Diseases of the adrenal gland occur rather more frequently than is appreciated and provide a series of challenges for the treating practitioner.

Poikiloderma of Civatte is a common benign condition of the sun-exposed areas of the neck characterised by atrophy, telangiectasia and pigmentation changes.

The primary care physician has an essential role in providing women with guidance, counselling and assessment regarding fertility concerns.