An otherwise well girl aged 11 months presented to her general practitioner with an unusual lesion on her posterior neck.

A woman aged 39 years presented with a 12-year history of recurrent painful nodules and boils to the axillae and pubic areas.

A woman aged 20 years presented with a more than three-month history of a scaly, erythematous rash to the groin.

A woman aged 64 years presented with a three-year history of vulvar itch and skin fragility with associated superficial dyspareunia.

A woman aged 19 years sustained a minor puncture wound to her left inner thigh while travelling in remote outback Australia.

This is a case study on toxic epidermal necrolysis.